HAPPI GWAS: Holistic Analysis with Pre- and Post-Integration GWAS
نویسندگان
چکیده
منابع مشابه
Gwas
That’s interesting. Care to elaborate? Part of the problem in trying to make a movie about real animals is that they aren’t actors. You can write a script — and there was one — but the chimps didn’t always follow it! So, like a good field worker, one had to adapt as the film footage came in and the story line changed. In this day and age of global warming, disease pandemics, and the like, it’s ...
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Summary While the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and Java-based program for post-GWAS analysis that predicts likely disease genes given a list of GWAS-reported variants. Designed with a command line ...
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In the recent decade, high-throughput genotyping and next-generation sequencing platforms have enabled genome-wide association studies (GWAS) of many complex human diseases. These studies have discovered many disease susceptible loci, and unveiled unexpected disease mechanisms. Despite these successes, these identified variants only explain a small proportion of the genetic contributions to the...
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Genome-wide association studies (GWAS) identify genetic variants that distinguish a control population from a population with a specific trait. Two challenges in GWAS are: (1) identification of the causal variant within a longer haplotype that is associated with the trait; (2) identification of causal variants for polygenic traits that are caused by variants in multiple genes within a pathway. ...
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nce upon a time, medical genetics was a relaOtively straightforward business: one gene—one protein—one disease was sufficient to explain most inherited disease and was neatly in keeping with Gregor Mendel’s discovery of alleles with his famous peas. The concept remains a good starting point but the biology of life is somewhat more complex, and increasingly we have become impressed and perplexed...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2020
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btaa589